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A prospective, placebo-controlled, randomized, single-blind phase II trial was conducted in a multidisciplinary university hospitals ICU where two groups of patients with systemic inflammatory response syndrome aged more than 18 years were randomized to receive either placebo or intravenous Se as a bolus-loading dosage of 2000 g Se followed by a continuous infusion of 1600 g Se per day for ten days, the study revealed that Se supplementation improved illness severity, and reduces the risk of VAP [90]

[DOI] [PMC free article] [PubMed] [Google Scholar] [30].Graham DL, Madkour HS, Noble BL, et al